P5P is the bioactive coenzyme form of vitamin B6, required for over 100 enzymatic reactions in the body. It is more efficient than pyridoxine HCl because it does not require conversion by the liver.
Functions:
Supports neurotransmitter synthesis (serotonin, dopamine, GABA)
Enables protein, carb, and fat metabolism
Involved in hemoglobin and myelin production
Helps regulate hormone activity and inflammation
TAILORBLEND uses P5P for its superior bioavailability, better tolerance, and lower required doses compared to pyridoxine HCl.
P5P (Pyridoxal-5-Phosphate) is the active form of vitamin B6, commonly used to support:
Mood, focus, and sleep (via neurotransmitter production)
Hormonal balance and PMS symptom relief
Energy metabolism and red blood cell formation
Homocysteine metabolism and cardiovascular support
Immune system function
Nausea in pregnancy (under medical guidance)
P5P is present naturally in animal foods. Other forms of B6 are found in plants and converted to P5P in the body.
Animal Sources:
Chicken, tuna, beef liver, salmon, eggs
Plant-Based Sources:
Chickpeas, lentils, brown rice, bananas, potatoes, sunflower seeds, spinach, fortified cereals
Synergistic Nutrients:
Magnesium: Supports calm mood, sleep, and PMS relief
B12 + Folate: Work with B6 in homocysteine metabolism
Zinc: Supports immune and hormonal function
5-HTP or tryptophan: Requires P5P for serotonin production
Typical Dosages:
Maintenance: 2–10 mg/day
Functional support: 10–25 mg/day
Therapeutic (e.g. PMS, nausea, methylation): 25–50 mg/day
Do not exceed 100 mg/day long-term
Avoid exceeding 100 mg/day from supplements unless under medical supervision.
Possible interactions with medications such as levodopa, isoniazid, and anti-epileptic drugs.
Consult a healthcare provider if pregnant, breastfeeding, or managing chronic conditions.
NIH Fact Sheet on Vitamin B6: ods.od.nih.gov
Linus Pauling Institute: lpi.oregonstate.edu
Wyatt et al., BMJ (1999) – B6 for PMS: PubMed Link
Merete et al., Am J Clin Nutr (2010) – B6 and depression in older adults
Shenkin et al., Am J Clin Nutr (1985) – B6 and asthma response